Atezolizumab Immunotherapy Is Withdrawn From FDA-Approval Process
Understand more about the change in approval for Atezolizumab (Tecentriq®) for TNBC.
Cell-Based Therapies: A Type of Immunotherapy for MBC
What is the difference between CAR T-cell therapy, TCR therapy, TIL therapy, NK cell therapy, and Bria-IMT? Learn more here.
Cell-Based Therapies: A Type of Immunotherapy for MBC
What is the difference between CAR T-cell therapy, TCR therapy, TIL therapy, NK cell therapy, and Bria-IMT? Learn more here.
Immunotherapy Resistance
Learn more about immunotherapy resistance and current clinical trials on metastatic breast cancer immunotherapy.
Update on Oral SERDs for Estrogen Receptor-Positive MBC
Learn about oral SERDs in clinical trials for ER+ MBC.
Lymphodepletion in Cancer Immunotherapy
Learn what lymphodepletion is, why it is used during immunotherapy treatment, the pros and cons of lymphodepletion, and the related research.
Local Therapies for Liver Mets
Learn how liver mets are currently managed and what newer research has found.
Y-90 Internal Radiation Therapy for Liver Mets
Local therapy is important for managing symptoms related to MBC with liver mets. Learn how Yttrium-90 internal radiation therapy (Y-90) may increase survival.
The Tumor Microenvironment
Scientists have discovered that the microenvironment–the cells that surround a tumor–plays a role in both how tumors grow and how they respond to treatment. Researchers also think that certain treatments, like immune checkpoint inhibitors, work in part because of the effect they have on the tumor’s microenvironment.
Below you will find articles and video presentations that discuss the microenvironment, different avenues of tumor microenvironment research scientists are pursuing, and clinical trials listed on BreastCancerTrials.org studying a treatment’s affect on a tumor’s microenvironment.
Tumor microenvironment
- Nature: The Tumor Microenvironment
- Addgene: The Breast Cancer Microenvironment: A Tumor’s Backstage Team
- Cold Spring Harbor Laboratory (Video): Battling Breast Cancer: Understanding the Tumor Microenvironment
Tumor microenvironment and MBC
- Share Cancer Support: Metastatic Breast Cancer and The Tumor Microenvironment
- Journal of Cancer Metastasis and Treatment: Breast Cancer, Metastasis and the Microenvironment
Tumor microenvironment related clinical trials
- Metastatic Trial Search: Metastatic Clinical Trials Targeting the Microenvironment
- National Cancer Institute (webinar by Dr. Alexandra Harris): What the tumor microenvironment is and how it is being studied to benefit people with cancer (skip to 29:00)
What is Oligometastatic Breast Cancer?
Women and men with metastatic breast cancer are typically told their cancer can be treated but not cured. This is true for most patients. But there are some patients who have only a small number of metastatic sites who doctors think may potentially have a different outcome. These patients have what is called oligometastatic breast cancer (OBC, oligo is Greek for few).
It is estimated that up to 20% of metastatic breast cancer patients have OBC. Oligometastases is not unique to breast cancer; it is seen in patients with other types of cancers as well. Studies have shown that tumors found in patients with oligometastatic cancer (OC) are biologically different from those seen in patients who have multiple sites of metastases. Whether OC responds to treatment better or is just slow growing isn’t clear.
Some of the articles below discuss OC in general. Others discuss OBC specifically. Each can help you better understand this subset of metastatic cancer and why researchers believe it could, potentially, be cured.
Oligometastatic Breast Cancer (OBC)
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- Cancer.gov: A More Treatable Kind of Metastatic Cancer?
- Indian Journal of Medical and Paediatric Oncology: OBC: A Mini-Review
- Breast Care: OBC: Shifting Treatment Focus
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Oligometastatic Cancer (OC)
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- Targeted Oncology: OC: Broadening Path to Cure
- Cancer World: Pushing the Boundaries of Curative Treatment
- OncLive: Stereotactic Radiotherapy for OC
- Clinical Oncology: The Dandelion Dilemma Revisited for Oligoprogression
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Visit Metastatic Trial Search to find trials for oligometastatic breast cancer.