What Are Master Protocols?

bctt on March 2, 2019

Master protocols are clinical trials that are specifically designed to allow researchers to study several molecular markers and targeted therapies simultaneously. These protocols also allow researchers to introduce new therapies into a trial that is already underway.

Researchers are still learning the best way to design these protocols and choose the proper statistical methods for evaluating their findings. Here you can read about how master protocols are being used in breast cancer and other clinical trials.

Want to learn more? The February issue of MTT discussed two types of master protocols: basket trials and umbrella trials.

¿Hablas Español?

bctt on March 2, 2019

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We want to help Spanish-speaking women and men with metastatic breast cancer learn about clinical trials and how they can find studies that might be right for them.

Below is a list of websites about MBC created specifically for Spanish-speaking patients. We hope you will share this information with your Spanish-speaking friends and relatives.

Know of other sites you think we should add to the list? Please email us. 

Queremos ayudar a las mujeres y hombres de habla hispana con cáncer de mama metastásico a aprender acerca de los ensayos cla­nicos y cómo pueden encontrar estudios que puedan ser adecuados para ellos.

A continuacian hay una lista de sitios web sobre MBC creados especa­ficamente para pacientes que hablan español. Esperamos que comparta esta información con sus amigos y familiares que hablan español.

¿Conoces otros sitios que crees que deberamos agregar a la lista? Por favor envíenos un correo electrónico: metastatictrialtalk@gmail.com

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Learn From Home With a Webinar

bctt on March 2, 2019

Many organizations and advocacy groups provide webinars, on-line workshops, and videos to help patients learn more about metastatic breast cancer and clinical trials.

These webinars provide an excellent opportunity to get in-depth information from health care providers and advocates without attending a conference and at a time that is convenient to you.

Get started watching and learning with the list below. And check out our Calendar to see what’s to come.

Know about a great webinar that’s not on our list? Email us.

Recorded Webinars

Get the Latest News on PARP Inhibitors

bctt on February 4, 2019

There are now two PARP inhibitors that have been approved to treat certain types of metastatic breast cancer. Clinical trials of other PARP inhibitors are now underway.

You can learn about the drugs that have been approved and where the research is headed in the articles and videos below.

You can also see all of the breast cancer clinical trials studying PARP inhibitors below.

PARP Inhibitors: Overview and Current Status 

PARP Inhibitor Therapy: Who & How

PARP Inhibitors: Challenges and Opportunities

Current PARP Inhibitors Trials:

All about Basket and Umbrella Trials

bctt on February 4, 2019

Basket trials and umbrella trials were created to help researchers study how tumors respond to targeted therapies.

Basket trials, also known as bucket trials, enroll patients whose tumors have a specific genetic mutation, regardless of where their cancer started.

Umbrella trials enroll patients with one type of cancer and have many different treatment arms. Patients are assigned to a specific arm based on the biomarkers seen in their tumor.

The articles below explain the goals of these trials. They also discuss potential challenges and concerns.

You can find all the basket trials enrolling breast cancer patients from BreastCancerTrials.org

Understand Basket and Umbrella Trials

Basket and Umbrella Trials: Past and Now

Basket Trials: Advantages, Challenges and Opportunities

Current Basket Trials:

Consider a Retreat

bctt on February 4, 2019

Whether it’s one day or week, a retreat can provide an opportunity to form important connections with others and gain skills that can help you live with metastatic breast cancer. Retreats also provide new experiences, a break from the day-to-day, great food, and more! These are some of the organizations and programs that provide retreats that may be of interest to individuals living with metastatic breast cancer.

What is CAR-T Cell Immunotherapy?

bctt on February 4, 2019

CAR-T is a personalized immunotherapy made from a patient’s white blood cells. The blood cells are removed from the patient and then modified with chimeric antigen receptors (CARs) so they can attack specific proteins. The cells are then infused back into the patient in the hospital.

CAR-T therapy has been approved for treating certain types of blood cancers. Clinical trials are now underway to see if it will be effective in treating metastatic breast cancer. You can find the breast cancer CAR-T trials now enrolling patients below.

CAR-T Therapy: An Overview

Current CAR-T Trials:

More immunotherapy articles on breastcancertrialtalk.org/